There has been some slight doubt surrounding the Sweden international after he was among four players rested for Sunday’s 3-1 FA Cup third round victory over Bromley.
Isak can break one of Alan Shearer’s records this evening by becoming the first Magpies player to net in eight consecutive Premier League games.
“He will be there or thereabouts,” Eddie Howe said on the striker fitness. “We haven't seen him train yet, but fingers crossed he will be.
“He'd be desperate to play, of course. Those [scoring] runs I'm not really too focused on and not too interested in, but I understand the individuals will care deeply about them.
“I'd love Alex to continue to score. I think the most important thing for me is that the team is functioning well for him and he's functioning well for the team, the two things go hand-in-hand together.
“We have looked like scoring goals recently, that's such a big thing for our confidence levels, he's played a big part in that, hopefully that continues.”
Meanwhile, United will check on the fitness of Sven Botman, Jacob Murphy and Joe Willock.
“Yeah, we'll have a look at them again today,” said Howe. “They were left out for genuine reasons. So, all different things, but nothing major, we hope. So, minor problems that we needed to settle down, fingers crossed they'll be there or thereabouts.”
Howe, however, will definitely be without Harvey Barnes after the winger sustained a thigh muscle injury against Bromley.

1. GK: Martin Dubravka
A week ago, the Slovakian seemed set to join Al Shabab but now he’s more than likely to stay beyond January. | Getty Images

2. RB: Tino Livramento
Livramento is set to come back into the team in place of Kieran Trippier, who played a full 90 minutes vs Bromley on Sunday. | AFP via Getty Images

3. CB: Sven Botman
Botman or Fabian Schar? It’s the toughest selection call Howe has to make. | Getty Images

4. CB: Dan Burn
Burn has been outstanding throughout Newcastle’s winning run. At the moment, he’s impossible to drop. | Getty Images