The fixture was originally scheduled to take place on Sunday 2nd January, but a combination of positive Covid cases and injuries in the Magpies came led to the game being postponed.
Eddie Howe’s side travel to St Marys in fine form after winning five and drawing three of their last eight games to move seven points and four places clear of the drop zone.
NewcastleWorld takes a look at the latest ahead of yet another crucial clash for the Magpies:
Is Southampton v Newcastle being shown live on television?
In short, no.
There is no live television broadcast of the game in the UK, with Amazon Prime choosing to focus on Leeds United’s home against Aston Villa.
However, highlights from the game will be available on Sky Sports YouTube channel later that evening as well as on both clubs’ websites.
How can I keep up-to-date with the game?
NewcastleWorld will be represented at St Mary Stadium with Jordan Cronin and Liam Kennedy both making the long trip to the South Coast.
Alternatively, BBC Newcastle will have full-match commentary of the game.
What is the latest ahead of the game?
Newcastle are once again without the services of key players Kieran Trippier and Callum Wilson, but Matt Ritchie has returned to training.
Allan Saint-Maximin is in contention for a starting place - although Howe suggested the winger is not yet at full fitness in his pre-match press conference.
Southampton will assess the fitness of defender Mohammed Salisu and are definitely without Nathan Tella and Alex McCarthy.
What are both managers saying?
Newcastle United manager Eddie Howe said: “We are looking for a performance and a result.
“They (Southampton) have done very well at home this season and that’s for a reason.
“They play an intense game out of possession. The have got some really good patterns of movement in possession so we need to be at our best.”
Howe’s opposite number Ralph Hasenhüttl spoke of the United boss, saying: “They have stabilised the team, stabilised the club and stepped out of the relegation zone.
“There is not really a big threat of relegation anymore and they are on a good run of form.
“It will be an interesting game.”
What are the latest odds?
Southampton are rated as 19/20 favourites to claim a win with SkyBet, with Newcastle rated 11/4 to continue their upturn in form with a win at St Marys.
The draw is priced at 13/5.