Newcastle United make the daunting trip to Anfield, a ground they haven’t won on since 1994.
The impossible task? It feels that way against a Liverpool side who are back to their potent best - sitting second in the Premier League, four points behind leaders Manchester City.
GK: Martin Dubravka
Conceded four last time out but no reason to drop Dubravka. Will need to be at his very best if Newcastle are to somehow get something at Anfield - or at least keep the score down.
RB: Javier Manquillo
Endured an awful afternoon at Leicester as he was largely at fault for goals two and three. A potential change in Jacob Murphy is perhaps a tad dangerous against a world-class Liverpool attack given the question marks over his ability to defend.
CB: Fabian Schar
Now Federico Fernandez is out injured, there aren’t many other options? Emil Krafth perhaps? Although he inspires little confidence. Schar, for what he lacks in physicality, is United’s best defender with the ball.
CB: Jamaal Lascelles
There have been calls from supporters to drop Lascelles after the Leicester penalty incident but Howe has vowed to stick by his captain. That faith needs repaid.
CB: Ciaran Clark
With a change to a back five predicted, Clark would naturally be recalled to the starting XI. He’s got a lot of making up to do after his Norwich red card.
LWB: Matt Ritchie
Ritchie is a player Howe knows and trusts immensely. Harsh on Jamal Lewis, but it wouldn’t be a surprise to see Ritchie restored to the starting XI.
CM: Isaac Hayden
With Shelvey and Willock together, Newcastle lack that holding midfielder. Such role could be key against Liverpool, and Hayden is recognised as someone who can do that.
CM: Jonjo Shelvey
Some games can pass Shelvey by, as did Leicester, but when out of the team, Newcastle have missed him this season. Remains a key player under Howe, who described him as an “unbelievable technician”.
The Brazilian showed against Norwich his ability to drop deeper in midfield. This role would help him support Shelvey, Hayden and the defence, as well as the attackers.
ST: Allan Saint-Maximin
Saint-Maximin hasn’t been his influential self on the left-wing, so perhaps a return to a role down the middle, where he excelled at times this season and last, will get him firing again.
ST: Callum Wilson
With Wilson’s injury record, his gametime must be managed accordingly - but Howe knows that more than anyone. It’d make sense to rest the 29-year-old, but who replaces him? Dwight Gayle?