Summer signing Lewis Hall started the 2-0 defeat to AFC Bournemouth last time out but is unable to feature against his parent club. The 19-year-old is on a season-long loan from the Blues before he completes a permanent switch next summer.
Further up the pitch, Howe is keeping a close eye on Sean Longstaff. The Geordie midfielder picked up an ankle injury on the South Coast and his involvement today is subject to a late fitness test.
Bruno Guimaraes, however, is back from his one-match suspension while 17-year-old Lewis Miley also impressed on his first Premier League start.
In attack, Newcastle fans will be hoping to see Alexander Isak's name on the teamsheet. The club's record-signing has been sidelined for a month with a groin issue and the visit of Chelsea was earmarked as a return date.
When asked about the Swede at his pre-match press conference though, Howe stayed very coy.
"I don't want to give too much away," he said. Newcastle are currently without 10 senior players through either injury or suspension.
Here's our predicted Newcastle United starting XI for the Premier League clash against Chelsea.