Manchester City and Newcastle United go head-to-head for the fourth time this campaign with a place in the FA Cup semi-finals at Wembley up for grabs.
Pep Guardiola's men have recorded a Premier League double over the Magpies this season, winning 1-0 at the Etihad Stadium in August before Oscar Bobb's stoppage time winner claimed a dramatic victory at St James' Park in January.
While City have got the upper hands on United in the league, Eddie Howe's men did dump them out of the Carabao Cup at the third round stage in September with Alexander Isak scoring the only goal of the game.
But the challenge of facing last season's triple winners remains one of the hardest assignments in world football, and it goes without saying that Newcastle will need to be at their very best of they are to advance into the last four of the FA Cup for the first time in 20 years.
The Magpies may be boosted by the news that Kevin De Bruyne and Ederson won't be involved after they picked up injuries away to Liverpool last time out.
However, Newcastle have their own injury problems, as they have done all season. Anthony Gordon is the latest injury scare after a knee injury forced the winger to withdraw in the first-half against Chelsea on Monday.
We take a look at the latest injury news from both camps ahead of this evening 5:30pm kick-off.
1. OUT: Sandro Tonali (Newcastle United)
The Italian is suspended from football until August due to illegal gambling activity
2. OUT: Kevin De Bruyne (Manchester City)
Belgian midfielder Kevin De Bruyne picked up an injury against Liverpool and has been withdrawn from Belgium's international squad.
3. OUT: Callum Wilson (Newcastle United)
The England striker is not expected to return until the final weeks of the season after he suffered a chest injury in last month's win against Nottingham Forest.
4. OUT: Ederson (Manchester City)
The Brazil international is set for a period on the sidelines after suffering a knee injury in Sunday's draw with Liverpool. Photo: PAUL ELLIS