You have to go back 11 years for the last - and only - time the Magpies have won away to Manchester United in the Premier League era when a Yohan Cabaye goal secured a 1-0 win.
And this may be the first time Newcastle have gone into it as favourites. Eddie Howe’s side sit fifth in the the table, seven points and nine places above the Red Devils, who lost 2-0 to Wolverhampton Wanderers on Boxing Day.
"They're very difficult fixtures regardless of when you go but I think, for us, we try and attack the game as we have done in recent weeks,” said Howe. “We've had really good preparations to our games and the players seem to be enjoying themselves, entering the game with the right frame of mind to play.
"We've got to try and hit that sweet spot again without any distractions. I'm sure the players will be ready for the games."
Newcastle will check on the fitness of Kieran Trippier and Tino Livramento following the 3-0 win over Aston Villa. Trippier got through 78 minutes on his first start since October while Livramento missed out through illness.
Meanwhile, Man United will be without Bruno Fernandes and Manuel Ugarte because of suspension. Here’s the early team news from both camps:
1. Sven Botman - doubt
Botman is closing in on a first-team return after featuring for the under-21s earlier this month. Newcastle are just waiting for the right moment to recall him to the matchday squad. | Getty Images
2. Tino Livramento - doubt
Livramento missed the 3-0 win over Aston Villa through illness but should return for the visit to Old Trafford. | Getty Images
3. Jamaal Lascelles - out
Lascelles sustained an ACL injury just a couple of weeks after Botman in March. He could return around February time. | Getty Images
4. Callum Wilson - out
Having missed the opening three months of the campaign with a back and hamstring injury, Wilson suffered a setback earlier this month, ruling him out until February at the earliest. | Getty Images