Eddie Howe’s side headed into the international on the back of two straight 1-0 defeats at Chelsea and Everton.
They jetted off to Dubai for their second warm-weather training camp of the year before finishing off their Spurs preparations on Tyneside.
United hold a nine-point advantage over the Premier League relegation zone following a recent nine-game unbeaten, which included six wins out of seven.
However, now is time to ensure their excellent form doesn’t count for nothing by securing their top-flight status at the earliest opportunity.
In terms of his team selection ahead of the visit to North London, Howe has some tough calls to make.
Martin Dubravka and Fabian Schar are expected to be passed fit, while Jonjo Shelvey, after missing the last two games, is set to come back in contention.
Meanwhile, Bruno Guimaraes, Chris Wood, Miguel Almiron and Emil Krafth have all been on international duty - could that impact their selection?
Here, we predict Howe’s Newcastle United starting XI to face Antonio Conte’s Spurs:
1. GK: Martin Dubravka
Dubravka was forced to withdraw from the Slovakia squad last week due to an infection but returned to training for Newcastle on Thursday. Photo: Ian MacNicol
2. RB: Javier Manquillo (in for Emil Krafth)
Emil Krafth has been on international duty with Sweden, whilst Manquillo was a part of the squad that travelled out to Dubai. The Spaniard could get the nod because of that.
3. CB: Fabian Schar
Schar pulled out of the Switzerland squad after picking up an adductor injury just before the England friendly. Howe has confirmed the defender has trained ahead of Spurs.
4. CB: Dan Burn
Burn, recently voted the club’s Player of the Month for March, has created a solid defensive partnership with Schar. Photo: Stu Forster