Yoane Wissa bagged a brace off the bench to get Matthias Jaissle off to a flying start as Newcastle United manager.
Filip Ugrinic fired Valencia into an early lead with a curling effort from outside the area. Moments later, Anthony Elanga wrongfully had a goal disallowed before his night was cruelly ended due to a Jose Gaya horror challenge.
The resulting red card allowed the Magpies to take control - with Jaissle proactively making four changes at the break. Wissa and Bazoumana Toure, in particular, proved to be inspired substitutions.
The Toon No.9 scored shortly after the restart and looked lively throughout before combining with Toure late on to seal the victory. Here are your NewcastleWorld player ratings.
13. Sean Steur - 7
A class act again. His composure in midfield gave Newcastle control in the second half. | Getty Images
14. Jacob Murphy - 5
A one-trick pony. Hug the touchline, look up and cross. Put a decent ball in for Wissa but continues to look predictable. | Getty Images
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15. Mason Miley - 6
Like Shahar, he did not put a foot wrong at right-back. | Getty Images
16. Bazoumana Toure - 7
Pace to burn and his raw speed allowed him to create the winner. Needs to get on the weights, but Newcastle fans will like the glimpses that they saw from the young wideman. | AFP via Getty Images