Eddie Howe's side faced Paris Saint-Germain in the Champions League on Tuesday and came within minutes of claiming a historic 1-0 win, only for a controversial Kylian Mbappe penalty to level the scores in the eighth minute of stoppage time.
In order to qualify for the knockout stage, the Magpies must beat AC Milan and hope PSG fail to beat Borussia Dortmund. But in the meantime, Howe has three league matches to focus on.
A win against the Red Devils will see Howe's men climb above them in the league table.
“You can never underestimate the qualities of Manchester United," Howe said. "They are a very good team and have got outstanding individuals.
"They have a very good Head Coach who is leading them so, first and foremost, we have total respect to our opposition. They have won a lot of games recently and are performing well; they have quality players.
“For us, following on from the Chelsea game, we need to try and keep that momentum and energy from our recent performances, I think it will be a really good game.”
Here's our predicted Newcastle United starting XI.