Wilson, after assisting Miguel Almiron’s opener, did not re-emerge for the second half and was replaced by Chris Wood, who doubled his side’s lead. Trippier, meanwhile, limped off with 10 minutes to go.
“Callum wasn’t that well in the week and felt light-headed and dizzy so that’s why he came off,” Howe explained.
“It was a joint decision, he didn’t feel he had the energy needed and it was easy decision to replace him with Chris, who came on and got the job done.
“When you look at today’s performance it was below from where have been but we still won 4-1.”
On Trippier, Howe added: “I’m not sure what happened in terms of him getting treatment. He said he was fine at half-time to carry on. It was my decision to withdraw him at 3-0 just to protect him.”
The England right-back played an eye-of-the-needle pass for Joe Willock’s goal but was off the pitch when Romain Perraud pulled one back for the hosts before Bruno Guimaraes restored United’s three-goal advantage.
The win lifted Newcastle up to third in the Premier League. Howe said: “It’s important in our position now we do think back because last year we were in a really difficult position and it’s very quickly been forgotten so I’ve encouraged the players to really enjoy the moment we’re in now and really soak it in what they’re achieving because it was a very difficult game today. It’s a tough place to come and I thought the goals were the highlight in our performance.”