Alexander Isak is unlikely to play for Newcastle United before the World Cup break, while Allan Saint-Maximin has suffered another hamstring injury.
The club’s record signing was edging closer to a return after missing the Premier League wins against Fulham and Brentford with a thigh injury.
However, in the build-up to the 0-0 draw with Manchester United, the 22-year-old aggravated the problem.
And Eddie Howe has revealed Isak is set to remain on the sidelines until after the international break in November.
“Alex has reinjured his thigh, very similar to the first one he picked up with Sweden,” Howe said. “He’s going to be out for a period of time.
“We probably won’t see him before we break for the World Cup.”
Meanwhile, Saint-Maximin missed the goalless draw at Old Trafford having suffered an injury setback.
The Frenchman missed the previous five games before coming off the bench versus Brentford last week.
He was expected to be involved for the visit to Old Trafford but Howe has explained Saint-Maximin’s situation.
“Maxi’s got a very tight irritation of his hamstring,” Howe said. “The problem we have is on his own that would be very small and probably a few days about but because it’s the third time he’s done it, we have to be very careful with his return to play.
“Huge blows for us, they’re both very different cases.”