Dominic Calvert-Lewin is set to spend up to 10 weeks on the sidelines after injuring his knee during training.
The 25-year-old picked up the issue as Everton prepared for their Premier League opener against Chelsea on Saturday.
According to Football Insider, Calvert-Lewin has torn his lateral collateral ligament, which is set to rule the striker out for almost three months.
It’s another setback for the England international after missing large parts of last season with various injuries.
He made just 18 appearances in total as the Toffees battled Premier League relegation.
Calvert-Lewin was among Newcastle United’s top targets at the beginning of the summer window but were put off by Everton’s asking price.
Still, the interest remained in hope that Frank Lampard’s side lowered their valuation.
A move for Calvert-Lewin can almost definitely be ruled out now with the striker set to be out until November.
His injury leaves Everton without a recognised senior centre-forward for their clash against Thomas Tuchel’s Blues.
Richarlison was sold to Tottenham Hotspur earlier in the summer, while former United forward Salomon Rondon is suspended after being sent off against Brentford last season.
Newcastle, meanwhile, host newly-promoted Nottingham Forest with Callum Wilson set to lead the front line.