The Magpies spent close to £120million on four new signings after splashing a club record £58million on Alexander Isak.
United also landed their No.1 defensive target after months of trying with Sven Botman arriving from Lille.
Nick Pope was brought to the club as Newcastle’s first choice goalkeeper, while Matt Targett completed a permanent switch from Aston Villa.
There was also a number of outgoings, with the long-serving Isaac Hayden, Ciaran Clark, Freddie Woodman, Dwight Gayle and Martin Dubravka among those to depart.
In little under 12 months, Newcastle’s squad already looks very different after a significant amount of investment by the owners.
With that in mind, NewcastleWorld predicts the 25-man squad Howe will name:
5. Javier Manquillo
A steady back up should Kieran Trippier suffer an injurt at any point. | Getty Images
6. Sven Botman
The £35million summer signing has started three of United’s opening five Premier League games. | Getty Images
7. Dan Burn
Started every game for Newcastle so far - playing three games at left-back and two at centre-half. Photo: Jan Kruger
8. Jamaal Lascelles
The Magpies captain faces strong competition for a place in the starting XI. | AFP via Getty Images