Howe plans to ring the changes for the visit of Bilabo after beating Serie A side Atalanta 1-0 last night.
The likes of Nick Pope, Dan Burn, Matt Targett and Chris Wood - who scored the only goal of the game from the spot - won’t feature against Bilbao.
It was left to academy graduate Elliot Anderson to steal the show on Friday, which has strengthened his hopes of being part of Howe’s first team squad this season.
Minutes are key in pre-seasona nd Howe will have the opportunity to hand most players up to 90 minutes ahead of hosting Nottingham Forest next Saturday.
Here, NewcastleWorld takes a look at the starting XI Howe is expected to name against Bilbao:
5. LB: Paul Dummett
A full game might be too much for Dummett, who was left out against Benfica on Tuesday. Photo: Ian MacNicol
6. CM: Bruno Guimaraes
Will be hoping for a better display after a rare off day in Lisbon. | Getty Images
7. CM: Joelinton
Back available after sitting out the Atalanta friendly through suspension. | AFP via Getty Images
8. CM: Joe Willock
Played the second half against Benfica, | Getty Images