Victory against Aston Villa last time out lifted Eddie Howe’s side four points above the relegation zone.
And they now travel to the capital to take on David Moyes’ Hammers, who are eyeing a Champions League spot.
Howe will be without full-backs Kieran Trippier and Javier Manquillo after limping off last week.
Trippier is facing a fight to be fit again this season, while Manquillo is less serious and should be back within two weeks.
Meanwhile, summer signing Bruno Guimaraes is desperate to start after two cameo appearances from the bench against Everton and Villa.
Jamaal Lascelles is back from illness, giving Howe a big selection dilemma as he prepares to name his starting XI at the London Stadium.
Here’s the starting XI we’re predicting United’s head coach to go with:
5. LB: Matt Targett (in for Javier Manquillo)
Targett is set to return to the starting XI for his second NUFC appearance after he was ineligible to face his parent club Aston Villa last Sunday. Photo: Stu Forster
6. CM: Jonjo Shelvey
Shelvey has become a key cog in the midfield ever since Howe labelled the former Liverpool man as an “unbelievable technician” during his first week in the job. Photo: Stu Forster
7. CM: Joe Willock
This is the best Newcastle have seen of Willock since his £20million permanent move from Arsenal in the summer. Photo: George Wood
8. CM: Joelinton
Striker or forward turned midfield general. The Brazilian is simply undroppable at the moment. Long may the Joelinton revival continue. Photo: George Wood