Victory against Aston Villa last time out lifted Eddie Howe’s side four points above the relegation zone.
And they now travel to the capital to take on David Moyes’ Hammers, who are eyeing a Champions League spot.
Howe will be without full-backs Kieran Trippier and Javier Manquillo after limping off last week.
Trippier is facing a fight to be fit again this season, while Manquillo is less serious and should be back within two weeks.
Meanwhile, summer signing Bruno Guimaraes is desperate to start after two cameo appearances from the bench against Everton and Villa.
Jamaal Lascelles is back from illness, giving Howe a big selection dilemma as he prepares to name his starting XI at the London Stadium.
Here’s the starting XI we’re predicting United’s head coach to go with:
9. RW: Ryan Fraser
The arrival of Howe has transformed Fraser's fortunes on Tyneside as he prepares for his eighth consecutive start. Photo: LINDSEY PARNABY
10. LW: Allan Saint-Maximin
The Frenchman wasn’t at his creative best against Aston Villa but that's no reason to drop him. Everyone knows how vital he is to United’s success. Photo: OLI SCARFF
11. ST: Chris Wood
Wood is searching for his first Newcastle goal at the fifth attempt. Interestingly, Wood has scored more goals against West Ham than any other Premier League club. Photo: George Wood