Watford and Burnley are also in action this evening after the two sides played out a 0-0 draw at Turf Moor on Saturday evening.
The visit of Frank Lampard’s Toffees, who look resurged after a 4-1 win over Brentford in the FA Cup at the weekend, is the Magpies’ first competitive game in 17 days.
Victory for United will not only bolster their survival hopes but bring Everton into the relegation dogfight by going one point behind them.
Since Newcastle beat Leeds United 1-0 last time out, Howe has added three new signings to his ranks.
Bruno Guimaraes is a hugely exciting addition from Lyon, while the arrivals of Matt Targett and Dan Burn bring plenty of top-flight experience.
Will all three start, joining Kieran Trippier and Chris Wood in the line-up? Well, we’re predicting one player to miss out.
1. GK: Martin Dubravka
Kept his second clean sheet of the campaign at Leeds United last time out. Will be hoping for another against Everton. Photo: Stu Forster
2. RB: Kieran Trippier
The England international has settled straight into life on Tyneside - winning the club's Player of the Month award for January. Photo: Stu Forster
3. CB: Fabian Schar
Schar has featured in all but one of Howe's 11 games in charge with his ability on the ball something that United's head coach really likes. Photo: Stu Forster
4. CB: Jamaal Lascelles
Lascelles, Newcastle's captain, is likely to retain his place after recovering from a hamstring injury picked up at Leeds. Deadline day signing Dan Burn may have to settle for a place on the bench with the defender affected by a toe injury in recent days. Photo: Stu Forster