Watford and Burnley are also in action this evening after the two sides played out a 0-0 draw at Turf Moor on Saturday evening.
The visit of Frank Lampard’s Toffees, who look resurged after a 4-1 win over Brentford in the FA Cup at the weekend, is the Magpies’ first competitive game in 17 days.
Victory for United will not only bolster their survival hopes but bring Everton into the relegation dogfight by going one point behind them.
Since Newcastle beat Leeds United 1-0 last time out, Howe has added three new signings to his ranks.
Bruno Guimaraes is a hugely exciting addition from Lyon, while the arrivals of Matt Targett and Dan Burn bring plenty of top-flight experience.
Will all three start, joining Kieran Trippier and Chris Wood in the line-up? Well, we’re predicting one player to miss out.
9. RW: Ryan Fraser
The arrival of former boss Howe has sparked a mini-revival for Fraser with the Scotland international enjoying a regular spot in the starting XI. Photo: George Wood
10. LW: Allan Saint-Maximin
Saint-Maximin’s inclusion speaks for itself, doesn’t it? While the Frenchman can dip in and out of games, he possesses an individual quality that not many Premier League forwards have in their locker. Can win any game on his own, as he has done for Newcastle in the past. Photo: Stu Forster
11. ST: Chris Wood
With Callum Wilson out injured until potentially April, it's Wood's job to carry the goalscoring burden. No pressure for the £25million January signing from Burnley. Photo: Stu Forster