Watford and Burnley are also in action this evening after the two sides played out a 0-0 draw at Turf Moor on Saturday evening.
The visit of Frank Lampard’s Toffees, who look resurged after a 4-1 win over Brentford in the FA Cup at the weekend, is the Magpies’ first competitive game in 17 days.
Victory for United will not only bolster their survival hopes but bring Everton into the relegation dogfight by going one point behind them.
Since Newcastle beat Leeds United 1-0 last time out, Howe has added three new signings to his ranks.
Bruno Guimaraes is a hugely exciting addition from Lyon, while the arrivals of Matt Targett and Dan Burn bring plenty of top-flight experience.
Will all three start, joining Kieran Trippier and Chris Wood in the line-up? Well, we’re predicting one player to miss out.
5. LB: Matt Targett
With Paul Dummett and Matt Ritchie unavailable, it's between Targett and Manquillo for the starting spot at left-back. Will Howe throw the loan signing from Aston Villa straight into the mix? Photo: Ryan Pierse
6. CM: Bruno Guimaraes
Seeing Guimaraes, the club's £33.5million January signing from Lyon, in the starting XI would give the St James' Park crowd a huge lift. Photo: SCOTT HEPPELL
7. CM: Jonjo Shelvey
Scored the winner at Leeds United last time out and there's no doubt Howe is a big fan of Shelvey, labelling him an “unbelievable technician” during his first week in the job. Photo: Stu Forster
8. CM: Joelinton
Howe confirmed Joelinton is "looking good" ahead of Everton after a groin injury forced him off at Leeds. Here's to hoping he can form a Brazilian double act with Guimaraes... Photo: Stu Forster