The event will collect funds for children's charity KidsOut, raising awareness and financial support for disadvantaged children in the region.
Keegan will take to the home of Sunderland for the upcoming black-tie event on Thursday, October 20.
On the night, guests will compete in teams to take part in games based on the hit TV show A Question of Sport.
There will also be a three-course meal and champagne reception.
Kevin Keegan said: "I was thrilled to be invited to help kick off the inaugural North East Kids Out Question of Sport event.
"I've been involved with many of these events over the years and I know it's a great event which supports a fantastic charity.
"I know people in the North East will really get behind this and I can't wait to be back again."
Keegan scored 48 goals in 78 appearances for The Magpies and famously managed The Entertainers side between 1992 and 1997.
Keegan works with charity KidsOut who strike to give children with difficult starts to life greater happiness, whether they have been victims of domestic violence or live in daily poverty.
Local organisations including Gleeson Homes, law firm Ward Hadaway, development land agents Wisemove, development consultants Pegasus Planning and Durham County Cricket Club will attend and support the Question of Sport event later this year.
Neil Reaney, Operations Director for Gleeson Tees Valley and its representative on the committee, commented: “Having been involved in the Yorkshire KidsOut event for some considerable years I know this is going to be a fantastic evening of entertainment with lots of fun and games but, the main aim is to bring together lots of North-East organisations together in one room and try and raise much-needed funds for this brilliant charity in what we hope will be one of the biggest industry networking events of the year.
"We also hope to be supported by a number of sporting celebrities past and present on the evening.
“Kevin Keegan needs no introduction here in the North-East and as a committee, we are delighted he has shown his support for this event.”
Gordon Moulds, CEO at Kids Out, added: "Kids Out provides significant support to children that have escaped domestic violence and I am delighted that our first-ever major Newcastle fundraising event is taking place.
"This will provide Kids Out with the funds it needs to continue to support every child in a Woman’s refuge in the North East."
Those interested in attending can book a table by contacting KidsOut here.